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Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy
文献类型:期刊
作者:Huang, Ling-Li[1]  Huang, Ling-Wei[2]  Wang, Lei[3]  Tong, Ben-Ding[4]  Wei, Qing[5]  Ding, Xuan-Sheng[6]  
机构:[1]China Pharmaceut Univ, Dept Clin Pharm, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.;
[2]Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Inst Special Environm Biophys, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;
[3]Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Pharm,Jiangsu Canc Hosp, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China.;
[4]Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Pharm,Jiangsu Canc Hosp, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China.;
[5]Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Pharm,Jiangsu Canc Hosp, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China.;
[6]China Pharmaceut Univ, Dept Clin Pharm, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.;
通讯作者:Ding, XS (reprint author), China Pharmaceut Univ, Dept Clin Pharm, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.; Wei, Q (reprint author), Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Pharm,Jiangsu Canc Hosp, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China.
年:2017
期刊名称:ONCOLOGY LETTERS影响因子和分区
卷:14
期:2
页码范围:1215-1222
增刊:正刊
收录情况:SCI(E)(WOS:000407904600002)  (28789336)  
所属部门:生命学院
人气指数:1590
浏览次数:1580
关键词:microRNA; microRNA-139-5p; cancer; diagnosis; prognosis; therapy
摘要:
MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a prom ...More
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