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Chronic Mild Stress Causes Bone Loss via an Osteoblast-Specific Glucocorticoid-Dependent Mechanism
文献类型:期刊
作者:Henneicke, Holger[1]  Li, Jingbao[2]  Kim, Sarah[3]  Gasparini, Sylvia J.[4]  Seibel, Markus J.[5]  Zhou, Hong[6]  
机构:[1]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;
[2]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Inst Special Environm Biophys, Sch Life Sci, Xian 710000, Shaanxi, Peoples R China.;
[3]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;
[4]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;
[5]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;Univ Sydney, Concord Hosp, Dept Endocrinol & Metab, Sydney, NSW 2139, Australia.;
[6]Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.;Univ Sydney, Concord Hosp, Dept Endocrinol & Metab, Sydney, NSW 2139, Australia.;
通讯作者:Zhou, H (reprint author), Univ Sydney, ANZAC Res Inst, Bone Res Program, Gate 3,Hosp Rd, Sydney, NSW 2139, Australia.
年:2017
期刊名称:ENDOCRINOLOGY影响因子和分区
卷:158
期:6
页码范围:1939-1950
增刊:正刊
收录情况:SCI(E)(WOS:000403230500039)  
所属部门:生命学院
被引频次:2
人气指数:282
浏览次数:278
基金:NHMRC [402462, 632819, APP1086100]; China scholarship council; Australian postgraduate award
摘要:
Chronic stress and depression are associated with alterations in the hypothalamic-pituitary-adrenal signaling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Using a transgenic (tg) mouse model in which glucocorticoid signaling is selectively disrupted in mature osteoblasts and osteocytes [11 beta-hydroxysteroid-dehydrogenase type 2 (HSD2)(OB)-tg mice], the present study examines ...More
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