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Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes
文献类型:期刊
作者:Yu, Jie[1]  Yin, Wenyan[2]  Peng, Tao[3]  Chang, Ya-nan[4]  Zu, Yan[5]  Li, Juan[6]  He, Xiao[7]  Ma, Xiaoyan[8]  Gu, Zhanjun[9]  Zhao, Yuliang[10]  
机构:[1]Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, 710129, China |Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[2]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[3]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[4]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[5]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[6]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[7]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[8]Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, 710129, China
[9]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China
[10]Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing, 100049, China |CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China
通讯作者:Ma, XY (reprint author), Northwestern Polytech Univ, Sch Sci, Key Lab Polymer Sci & Technol, Xian 710129, Shaanxi, Peoples R China.; Yin, WY; He, X; Gu, ZJ; Zhao, YL (reprint author), Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China.; Zhao, YL (reprint author), Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.
年:2017
期刊名称:NANOSCALE影响因子和分区
卷:9
期:13
页码范围:4497-4507
增刊:正刊
学科:物理学
收录情况:SCI(E)(WOS:000397968400016)  EI(20171403532404)  (28317980)  
被引频次:14
人气指数:134
浏览次数:127
基金:National Basic Research Programs of China [2016YFA0201600, 2015CB932104]; Beijing Natural Science Foundation [2162046]; National Natural Science Foundation of China [11621505, 31571015, 51372206, 21320102003]; Innovation Program of the Chinese Academy of Sciences [QYZDJ-SSW-SLH022]; Doctorate Foundation of Northwestern Polytechnical University [CX201323]
摘要:
Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4: Yb, Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i. g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in ...More
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