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Connexin 43 Channels are Essential for Normal Bone Structure and Osteocyte Viability
文献类型:期刊
作者:Xu, Huiyun[1]  Gu, Sumin[2]  Riquelme, Manuel A.[3]  Burra, Sirisha[4]  Callaway, Danielle[5]  Cheng, Hongyun[6]  Guda, Teja[7]  Schmitz, James[8]  Fajardo, Roberto J.[9]  Werner, Sherry L.[10]  Zhao, Hong[11]  Shang, Peng[12]  Johnson, Mark L.[13]  Bonewald, Lynda F.[14]  Jiang, Jean X.[15]  
机构:[1]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Peoples R China.;Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[2]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[3]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[4]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[5]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[6]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
[7]Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA.;
[8]Univ Texas Hlth Sci Ctr San Antonio, Dept Orthoped, San Antonio, TX 78229 USA.;
[9]Univ Texas Hlth Sci Ctr San Antonio, Dept Orthoped, San Antonio, TX 78229 USA.;
[10]Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA.;
[11]Univ Missouri, Sch Dent, Dept Oral Biol, Kansas City, MO USA.;
[12]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Peoples R China.;
[13]Univ Missouri, Sch Dent, Dept Oral Biol, Kansas City, MO USA.;
[14]Univ Missouri, Sch Dent, Dept Oral Biol, Kansas City, MO USA.;
[15]Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.;
通讯作者:Jiang, JX (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
年:2015
期刊名称:JOURNAL OF BONE AND MINERAL RESEARCH影响因子和分区
卷:30
期:3
页码范围:550-562
增刊:正刊
学科:生物学和生物化学
收录情况:SCI(E)(WOS:000350066900019)  (25270829)  
所属部门:生命学院
被引频次:34
人气指数:2835
浏览次数:2799
基金:NIH [AR46798, RR025687, AG041505, AG045040]; Welch Foundation [AQ-1507]; China 973 Program [2011CB710903]; National Natural Science Foundation of China [31328016, 31170812]
关键词:CX43; ANIMAL MODELS; OSTEOCYTES; ANALYSIS/QUANTITATION OF BONE
摘要:
Connexin (Cx) 43 serves important roles in bone function and development. Targeted deletion of Cx43 in osteoblasts or osteocytes leads to increased osteocyte apoptosis, osteoclast recruitment, and reduced biomechanical properties. Cx43 forms both gap junction channels and hemichannels, which mediate the communication between adjacent cells or between cell and extracellular environments, respectively. Two transgenic mouse models driven by a DMP1 promoter with the overexpression of dominant negati ...More
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