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Evaluation of osteoclast-derived exosomal miRNA under simulated microgravity conditions using next-generation sequencing
文献类型:期刊
作者:Ting Huyan[1]  Du, Yongyong[2]  Peng, Hourong[3]  Hu, Xuejiao[4]  Wu, Changrui[5]  Li, Qi[6]  Dong, Dandan[7]  Li, Jingbao[8]  Shang, Peng[9]  
机构:[1]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[2]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[3]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[4]Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610041, Sichuan, Peoples R China.;
[5]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Ophthalmol, Xian 710061, Shaanxi, Peoples R China.;
[6]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[7]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[8]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[9]Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
通讯作者:Shang, P (reprint author), Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Inst Special Environm Biophys, Sch Life Sci,Res & Dev Inst Shenzhen, Xian 710072, Shaanxi, Peoples R China.
年:2019
期刊名称:ACTA ASTRONAUTICA影响因子和分区
卷:161
页码范围:75-86
增刊:正刊
收录情况:SCI(E)(WOS:000473374700008)  EI(20192106963629)  
所属部门:生命学院
人气指数:42
浏览次数:42
基金:National Natural Science Foundation of China (NSFC) [31500688, 81502465, 81700823, 51477141]; Fundamental Research Funds for the Central Universities [31020160QD042]; Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University
关键词:miRNA; Exosomes; Microgravity; Osteoclasts; Next-generation sequencing
摘要:
important role of osteoclast-derived exosomes in bone remodeling of microgravity-induced osteoporosis has been validated. However, the underlying mechanism remains unclear. A set of total miRNAs expressed in osteoclast-derived exosomes may configure the specific signature of the bone tissue in the microgravity condition. This study aimed to investigate the miRNA expression profile of osteoclast-derived exosomes in simulated microgravity using next-generation sequencing. Cell culture supernatant ...More
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