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Iron-dependent cell death as executioner of cancer stem cells
文献类型:期刊
作者:Zhao, Bin[1]  Li, Xin[2]  Wang, Ye[3]  Shang, Peng[4]  
机构:[1]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[2]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[3]Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[4]Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China.;Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
通讯作者:Shang, P (reprint author), Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China.; Shang, P (reprint author), Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.
年:2018
期刊名称:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH影响因子和分区
卷:37
期:1
页码范围:79
增刊:正刊
学科:临床医学
收录情况:SCI(E)(WOS:000429710100002)  (29636068)  
所属部门:生命学院
重要成果类型:重要期刊
人气指数:3305
浏览次数:3305
基金:Science and Technology Planning Project of Shenzhen of China [JCYJ20170412140904406]; National Natural Science Foundation of China [51777171]
关键词:Iron; Cell death; Executioner; Cancer stem cells
摘要:This commentary highlights the findings by Mai, et al. that ironomycin, derivatives of salinomycin, exhibited more potent and selective therapeutic activity against breast cancer stem cells by accumulating and sequestering iron in lysosome, followed by an iron-mediated lysosomal production of reactive oxygen species and an iron-dependent cell death. These unprecedented findings identified iron homeostasis and iron-mediated processes as potentially druggable in the context of cancer stem cells.
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