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Deformation regimes of collagen fibrils in cortical bone revealed by in situ morphology and elastic modulus observations under mechanical loading
文献类型:期刊
作者:Yang, Peng-Fei[1]  Nie, Xiao-Tong[2]  Zhao, Dong-Dong[3]  Wang, Zhe[4]  Ren, Li[5]  Xu, Hui-Yun[6]  Rittvveger, Joern[7]  Shang, Peng[8]  
机构:[1]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.;
[2]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[3]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;
[4]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.;
[5]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.;
[6]Northwestern Polytech Univ, Inst Special Environm Biophys, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.;Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.;
[7]DLR, German Aerosp Ctr, Inst Aerosp Med, Div Muscle & Bone Metab, D-51147 Cologne, Germany.,Univ Cologne, Dept Pediat & Adolescent Med, Albertus Magnus Pl, D-50923 Cologne, Germany.;
[8]Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.;Northwestern Polytech Univ, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Youyi Xilu 127, Xian 710072, Shaanxi, Peoples R China.;
通讯作者:Shang, P (reprint author), Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Fictitious Coll Garden, Gaoxin Fourth South Rd 19, Shenzhen 518057, Guangdong, Peoples R China.
年:2018
期刊名称:JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS影响因子和分区
卷:79
页码范围:115-121
增刊:正刊
收录情况:SCI(E)(WOS:000425072300014)  EI(20180104600537)  (29291465)  
所属部门:生命学院
被引频次:2
人气指数:964
浏览次数:948
基金:National Natural Science Foundation of China [11502213, 81741127]; Natural Science Foundation research project of Shaanxi Province [2015JQ1024, 2016JQ8009]; Northwestern Polytechnical University Foundation for Fundamental Research [3102016ZY041]; TianZhou-1 Space Program of China manned space project [TZ-1]
关键词:Collagen fibril; Bone; in situ elastic modulus; Atomic force microscopy; Deformation mechanism
摘要:
The mechanical properties of the bone play a decisive role in the resistance of the bone to fracture. Clinically, the quantity of the bone in the mineral phase has been considered as the gold-standard indicator for the risk of bone fracture. However, the bone is a complex tissue with a hierarchical-structure consisting of organic matrix, mineral hydroxyapatite, and water. Collagen comprises up to 90% of the organic matrix in the bone, and is vital for its mechanical behavior. To date, the morpho ...More
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