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CRISPR disruption of TCTP gene impaired normal development in the silkworm Bombyx mori
文献类型:期刊
作者:Liu, Zu-Lian[1]  Xu, Jun[2]  Ling, Lin[3]  Zhang, Ru[4]  Shang, Peng[5]  Huang, Yong-Ping[6]  
机构:[1]Northwestern Polytech Univ, Fac Life Sci, Xian, Shaanxi, Peoples R China.;Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.;
[2]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.;
[3]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.;
[4]Northwestern Polytech Univ, Fac Life Sci, Xian, Shaanxi, Peoples R China.;Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.;
[5]Northwestern Polytech Univ, Fac Life Sci, Xian, Shaanxi, Peoples R China.;
[6]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.;
通讯作者:Huang, YP (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai 200032, Peoples R China.
年:2019
期刊名称:INSECT SCIENCE影响因子和分区
卷:26
期:6,SI
页码范围:973-982
增刊:增刊
收录情况:SCI(E)(WOS:000472577600002)  (29316276)  
被引频次:11
人气指数:22
浏览次数:22
基金:Strategic Priority Research Program of Chinese Academy of Sciences [XDA04020202, XDB11010600]; National Science Foundation of China [31420103918, 31530072]
关键词:Bombyx mori; CRISPR; Cas9; TCTP
摘要:
The translationally controlled tumor protein (TCTP) is a highly conserved and multifunctional protein with activities ranging from cytoskeletal regulation to transcription regulation in numerous organisms. In insects, TCTP is essential for cell growth and proliferation. Recently, TCTP has been reported to affect the innate intestinal immune pathway in the Bombyx mori silkworm, a lepidopteran model insect. However, the comprehensive physiological roles of TCTP in the silkworm remain poorly unders ...More
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